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Remarkably, gene expression profiling studies have shown that GHK-Cu treatment can shift aged fibroblasts toward more youthful gene expression patterns, reversing age-related changes in gene activity related to collagen production, matrix remodeling, inflammatory responses, and cellular senescence

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To enhance neuronal GSH concentrations, several studies have evaluated the chelation of synaptically released zinc using a thiol-containing chemical compound, N-acetyl-cysteine (NAC)